Nasal drug delivery has been recognized as a very promising route for delivery of therapeutic compounds. This interest arises from the different possible advantages presented by the nasal cavity, such as: the epithelium very vascularized and with a relatively large surface area available for drug absorption, the porous endothelial basement membrane, the direct transport of absorbed drugs into the systemic circulation thereby avoiding the first-pass effect hepatic present in peroral administra...
Bacteria need warm and moist surroundings to be able to reproduce. They can either reproduce by the process of asexual reproduction where they are split up into two or by cell division, a process called: binary fission. Binary Fission takes place in a bacteria cell when DNA replicates and then divides into two identical cells. The main difference between the two types of gram positive and gram negative bacteria is the makeup of their cell walls. The cell wall of the gram positive bacteria con...
ABSTRACT: At the Dolan DNA Lab Center, an experiment was conducted to investigate Alu gene insertion on two alleles at the PV-92 Locus on Chromosome 16. Twenty two students participated in the research in the laboratory. Students washed their mouth with saline solution to extract their DNA sample and gel electrophoresis was used to find their genotype. Six students were reported to have the Alu insertion present on both alleles; ten were reported to have Alu present on one allele and the rest...
Human genome project is an international research program, the largest of its kind, mainly focusing on understanding and mapping of all the genes of Homo sapiens. The project was originally meant to last 15 years but was completed in 13 years, it officially started in 1990 and ended in April 2003, it marked the . The Department of Energy and James D. Watson from the National Institutes of Health was the heads of the project and later in 1993 Francis Collins. It acquired help from other countr...
The effects of ultrasonic treatment on the structure and properties of Zr-based bulk metallic glasses at room temperature were investigated by nanoindentation, in situ high-pressure synchrotron diffraction and differential scanning calorimetry (DSC). Results show that the glassy characteristics of the samples were stable up to 31GPa. Furthermore, the hardness, bulk modulus, and distribution of reduced hardness improved after ultrasonic treatment. The DSC results indicate that ultrasonic treat...
Supplementary groups with more complex mechanisms are elucidated. The accurate mechanism of action of some antimicrobial agents still mysterious (Chambers, 2006). 1.13. Bacterial resistance to antimicrobial agents Bacterial resistance is a major medical problem, because it seriously limits the usefulness of many antibiotics. Usually some species of microorganisms may be susceptible to some chemotherapeutic agent and resistant to others. But development of strains against the drug, which are e...
Wedding & Gylys (2005) define Atelectasis disease as a condition brought about by inadequate gaseous exchange within the alveoli. This condition is said to arise from fluid consolidation or alveolar collapse and may wholly or partially affect one lung. It may generally be regarded as an unusual condition defined by the disintegration of lung tissue, inhibiting the normal respiration process (http://www.healthscout.com/ency/68/440/main.html ). This disease is generally caused by an obstruction...
Nuclear receptors are specific transcription factors which have common sequences and structures which are thought to bind as homodimers or heterodimers to specific consensus sequences of DNA referred to as response elements in the promoter region of certain gene targets. They either promote or repress transcription of these gene targets by binding to a variety of hydrophobic endogenous ligands which when bound to the receptor it leads to conformational changes in the receptor, allowing the re...
Dielectrics are nonconducting materials that can be polarized through applied electric field. When a dielectric material is placed between two conductor plates of capacitor, the polarization of the dielectric will increase the capacitance by a factor κ where κ is a dimensionless factor called dielectric constant [1]. The information of the dielectric constant is one of the most important parameter when designing capacitors or in other cases where a material might be expected to introduce capa...
ABSTRACT Estimation of quality assessment of Brassica germplasm provides the basis for rapeseed/mustard genetic improvement. Studies were undertaken to assess the B. napus genotypes for quality characteristics, and to evaluate B. napus germplasm for erucic acid and Glucosinolates using Near Infrared Reflectance Spectroscopy (NIRS). A total of 30 B. napus genotypes of local and exotic origin were characterized using molecular and biochemical approaches. The Biochemical assessment revealed the ...
